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KMID : 1098420140220050331
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Korean Journal of Medicinal Crop Science
2014 Volume.22 No. 5 p.331 ~ p.338
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Whitening and Anti-wrinkle Effects of Korean Native Dendrobium moniliforme Methanol Extract
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Jung Ho-Kyung
Jang Ji-Hun
Ko Jae-Hyung
Kang Byoung-Man
Yeo Jun-Hwan
Cho Jung-Hee
Cho Hyun-Woo
Bean Chul-Gu
Kim Seong-Cheol
Jung Won-Seok
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Abstract
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Dendrobium moniliforme (DM) is a valuable and versatile herbal medicine with the anecdotal claims of antioxidant and anti-inflammation. In the present study, we investigated the whitening and anti-wrinkling effects of DM under various conditions with B16F10 melanoma cells and human dermal fibroblasts. The DM extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DM extract effectively suppressed the α-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the α-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) and protein expression of tyrosinase were significantly attenuated by DM treatment. We also investigated the DM increased the production of type I procollagen and inhibited TNF-α-induced mRNA expressions of MMP-1, -3 in the human dermal fibroblast. These results indicate that DM may be a great cosmeceutical ingredient for its whitening and anti-wrinkle effects.
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KEYWORD
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Whitening, Anti-wrinkling, Dendrobium moniliforme, Melanin, Tyrosinase
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